The UCSF Environmental Research and Translation for Health (EaRTH) Center will accelerate both the pace of discovery and prevention of environmental exposures that affect reproduction and development to improve human health across the lifespan. Current approaches to uncover and address complex chronic diseases do not adequately incorporate the role of environmental factors, particularly during critical reproductive and developmental stages. Solving this complex problem requires partnerships across disciplines; mobilization of technology toward identification, intervention, and prevention; and education of future scientists, clinicians, and the public. The EaRTH Center supports research in environmental health sciences with the Integrated Health Sciences Facility Core, Bioassay Facility Core, Community Engagement Core, and a Pilot Project Program that will increase environmental health research at UCSF. These Cores converge to understand how exposures during development influence disease and to intervene and prevent exposures to improve health throughout the lifespan, especially among vulnerable and underserved populations in the San Francisco Bay Area and beyond. The EaRTH’s Center current membership of over 50 faculty spans all four UCSF schools and 16 disciplines and they are poised to promote and advance synergistic, multidisciplinary environmental health research.